Comparative
Cardiovascular Physiology
| Kenneth
R. Olson
Professor,
South Bend Center for Medical Education
Adjunct Professor, Biological Sciences
Ph.D.,
Michigan State University |
|
The
emphasis of this laboratory is on the mechanisms and evolution
of blood pressure and fluid volume regulation. Fish are
used in most studies because; 1) the fish cardiovascular
system is the evolutionary prototype of all vertebrates,
and 2) many of their physiological systems are uniquely
sensitive to the environment and can thereby be manipulated
experimentally. Similar studies are not possible with
terrestrial vertebrates. Current studies are focused on
the interactions of the autonomic nervous system, renin-angiotensin
system, kallikrein-kinin system, atrial natriuretic peptides,
and endothelium-derived vasoactive substances in the cardiovascular
control and fluid volume regulation during fluid and salt
loading and depletion. A variety of methods are employed,
including in vivo instrumented fish, in vitro isolated
organ and isolated smooth muscle studies. Techniques include
cardiovascular surgery, radioisotope and HPLC methodology,
second messenger RIA and electron microscopy.
Selected
Publications:
Duff,
D.W., Conklin, D.J. and Olson, K.R. (1997) Effect of atrial
natriuretic peptide on fluid volume and glomerular filtration
in the rainbow trout. J. Exp. Zool. 278:215-220.
Olson, K.R., Conklin, D.J., Farrell, A.P., Keen, J.E., Takei,
Y.,Weaver, L. Smith, M.P. and Zhang, Y. (1997) Effects of
natriuretic peptides and nitroprusside on venous function
in trout. Am. J. Physiol. 273:R527-R539
Takei, Y., Fukuzawa, A., Itahara, Y., Watanabe, T.X., Yoshizawa-Kumagaye,
K., Nakajima, K., Yasuda, A., Smith, M.P., Duff, D.W., and
Olson, K.R. (1997) A new natriuretic peptide isolated from
cardiac atria of trout, Oncorhynchus mykiss. FEBS Letters
414:377-380.
Zhang, Y., Weaver, L.J., Ibeawuchi, A. and Olson, K.R. (1998)
Catecholaminergic control of venous function in the rainbow
trout. Am. J. Physiol. 274:R1195-R1202.
Olson, K.R. (1997) The cardiovascular System. In: The Physiology
of Fishes (D.H. Evans, ed.) CRC press, Boca Ratron, FL.
p.129-154
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